Detalhe da pesquisa
1.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
2.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
3.
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
J Med Chem
; 64(17): 12790-12807, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34414766
4.
Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
ACS Omega
; 5(12): 6967-6982, 2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258933
5.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
6.
Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzyme.
Biol Chem
; 390(9): 931-40, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19558329
7.
Residue L143 of the foot-and-mouth disease virus leader proteinase is a determinant of cleavage specificity.
J Virol
; 82(9): 4656-9, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18305051
8.
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
J Med Chem
; 61(20): 9371-9385, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30256636
9.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
10.
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.
J Mol Biol
; 357(3): 964-74, 2006 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-16476442
11.
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model".
J Med Chem
; 64(3): 1762, 2021 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508187
12.
Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
J Med Chem
; 59(21): 9890-9905, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27748596
13.
Development of domain-selective angiotensin I-converting enzyme inhibitors.
Ann N Y Acad Sci
; 1056: 160-75, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16387685
14.
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
J Med Chem
; 57(6): 2789-98, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24568587
15.
2,4-Diaminothienopyrimidines as orally active antimalarial agents.
J Med Chem
; 57(3): 1014-22, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446664
16.
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
J Med Chem
; 56(21): 8860-71, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24099149
17.
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
J Med Chem
; 55(24): 11022-30, 2012 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23189922
18.
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
J Med Chem
; 55(7): 3479-87, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390538
19.
Novel orally active antimalarial thiazoles.
J Med Chem
; 54(21): 7713-9, 2011 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21966980
20.
Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling.
Biol Chem
; 387(4): 461-6, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16606345